Collagen-induced arthritis - Effect of cyclosporin A; Second report.
نویسندگان
چکیده
منابع مشابه
Effects of cyclosporin on collagen induced arthritis in mice.
We have studied the effect of the immunosuppressive agent cyclosporin on collagen induced arthritis in mice. Cyclosporin, when given prophylactically, was capable of suppressing the development of collagen induced arthritis and the immunological response to native type II collagen in a dose dependent manner. Furthermore, treatment with cyclosporin, started on the same day as the booster injecti...
متن کاملInhibitory effect of enzyme therapy and combination therapy with cyclosporin A on collagen-induced arthritis.
OBJECTIVE There is increasing interest in the use of combination therapy for rheumatoid arthritis and in the possibility of combining the conventional drug approach with newer antirheumatic therapy. The present study investigates the efficacy of long-term prophylactic enzyme therapy and combination therapy with cyclosporin A in rats with collagen-induced arthritis. METHODS Rats with collagen-...
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rheumatoid arthritis is a chronic inflammatory disease characterized by the sequestration of various leukocyte subpopulations within both the developing pannus and synovial space. this study was undertaken to examine the therapeutic potency of tindurin in experimental rheumatoid arthritis. collagen-induced arthritis (cia) was induced by intradermally immunization of lewis rats at the base of th...
متن کامل2008 Effects of Cyclosporin a on Collagen Arthritis
Collagen arthritis in rats is an animal model of polyarthritis that can be produced by an intradermal injection of homologous or heterologous native type II collagen emulsified in incomplete Freund's adjuvant (ICFA) 1 (1). The disease, which resembles human rheumatoid arthritis in many aspects (2), is not completely understood but appears to be the result of an autoimmune response to type II co...
متن کاملParadoxical effects of cyclosporin A on collagen arthritis in rats
The effect of the immunosuppressive agent cyclosporin A (CS-A) on collagen arthritis in Sprague-Dawley rats is investigated. A 14-d course of CS-A treatment at doses of 15 mg/kg per day or more, begun on the same day as type II collagen immunization, suppressed the development of arthritis as well as humoral and delayed-type hypersensitivity (DTH) skin test responses to type II collagen, possib...
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ژورنال
عنوان ژورنال: Orthopedics & Traumatology
سال: 1984
ISSN: 1349-4333,0037-1033
DOI: 10.5035/nishiseisai.33.217